Ferrous sulphate
Ferrous sulphate
CLINICAL USE
Iron deficiency anaemia
DOSE IN NORMAL RENAL FUNCTION
Prophylaxis: 200 mg dailyTherapeutic: 200 mg 2–3 times dailyM/R: 1–2 tablets daily
PHARMACOKINETICS
Molecular weight                           :278 %Protein binding                           :– %Excreted unchanged in urine     : – Volume of distribution (L/kg)       :–half-life – normal/ESRD (hrs)      :– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in normal renal function HD                     :Not dialysed. Dose as in normal renal functionHDF/high flux   :Not dialysed. Dose as in normal renal functionCAV/VVHD      :Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAntibacterials: reduced absorption of 4-quinolones and tetracyclinesDimercaprol: avoid concomitant use Mycophenolate: may significantly reduce absorption of mycophenolate ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
One 200 mg ferrous sulphate tablet contains 65 mg elemental ironAbsorption of iron may be enhanced with concurrent administration of ascorbic acidPhosphate binding agents, e.g. calcium carbonate or magnesium carbonate, reduce absorption of iron from the gutMonitor: serum iron, transferrin saturation and ferritin levels
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